Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

En s'interrogeant sur les enjeux philosophiques, littéraires, culturels et linguistiques des notions de libéralité et de libéralisme, dans leur lien avec l'adjectif "libéral", cet ouvrage collectif suggère l'existence d'une généalogie commune à ces trois notions. Il dessine ainsi les rapports unissant ce qui convient à l'homme libre et par extension à ce qui permet de l'éduquer et d'élargir ses vues (arts libéraux et éducation libérale), la libéralité entendue comme largesse et générosité mais aussi comme vertu d'user avec mesure de l'argent, (...) et enfin le libéralisme propre aux sociétés commerçantes, mais dont l'appel au seul marché ne suffit pas à préserver la liberté et la civilisation. Philosophes, littéraires, historiens des idées et sociologues se sont réunis pour interroger les liens du libéralisme avec la libéralité et pour cerner de l'antiquité au XIXe siècle ce que recouvrait l'appellation "être libéral"."--Page 4 of cover. (shrink)

In H.M. Advocate v. Grimmond1 the judge in a Scottish High Court trial refused permission for expert psychological evidence to be admitted on behalf of the Crown in a prosecution involving sexual offences against two children. The Crown had sought to lead an expert witness to explain to the jury about patterns of disclosure in child sexual abuse cases. The case was remarkable, not so much for the strict application of the longstanding rule in R. v. Turner that constrains the (...) use in the courtroom of expert evidence from the behavioural sciences, but for the way in which the arguments presented by the Crown in Grimmond resonate with enduring feminist critiques regarding the treatment of women in rape trials. The theoretical issues raised by the decision include the quest for context to counter rigid evidential frameworks, and the choice of a child sexual abuse case as the medium for challenging the boundaries of the admissibility of expert evidence in the courtroom. The ramifications of Grimmond are tangible as legislation intended to benefit children and women has already been enacted by the Scottish Parliament to ameliorate the effects of the decision. This article suggests that while this legislation should be given a cautious welcome it remains to be seen whether the heralded benefits will actually materialise. (shrink)

This symposium discusses J.-L. Dessalles's account of the evolution of language, which was presented in Why we Talk (OUP 2007).

This article explores some of the issues raised by Munchausen’s Syndrome by Proxy (MSbP) and the relationship between medicine and law, specifically the discourses which feature in the courtroom portraying motherhood and expectations of parenting. These discourses are often hidden yet play a determining role in prosecutions for alleged maltreatment of children involving medically unexplained infant death syndrome. We offer a critique of MSbP and seek to unveil the assumptions about mothers, the parent predominantly affected by the ‘diagnosis’, and mothering (...) that underlie the association of women accused of deliberating harming their children. We suggest such insights are valuable because although the syndrome has never acquired a clear medical or legal definition, it has had repeated appearances in the literature and courtroom over the last 25 years and has more recently attracted attention from government, health care practitioners, academics and the media. We explore these issues through an examination of two recent Court of Appeal decisions in England: those of Sally Clark and Angela Cannings. (shrink)

Few years pass without an attempt to interpret Theocritus, Idyll 7. The poem's narrative and descriptive skill, dramatic subtlety and felicity of language are mercifully more than adequate to survive these scholarly onslaughts, so I have less hesitation in offering my own interpretation. The poem's chief problems seem to me to arise from uncertainty as to: Who is the narrator, and why are we kept waiting until line 21 before we are told that he is called Simichidas? Who, or what (...) sort of man, is the goatherd Lycidas, whom he encounters on his way from town to the harvest festival? Answers to these questions fundamentally affect our interpretation of their exchange of songs, which occupies almost half the idyll, and of Lycidas' gift of his stick to Simichidas; and these interpretations will go far towards interpreting the poem as a whole. (shrink)

post hos elefantorum fulgentium formidandam speciem et truculentos hiatus uix mentes pauidae perferebant; ad quorum stridorem odoremque et insuetum aspectum magis equi terrebantur. COKNELISSEN, Mnemosyne, xiv , 280, comments: ‘Non intellego fulgentium. Minime audiendus est Wagnerus, qui fulgentes elephantes dictos esse contendit ob cutem glabram. Corrigendum puto ingentium. Porro non satis intellego quomodo hiatus elefantorum militibus pauorem incutere potuerit. Wagnerus, qui omnia con-coquere solet, interpretatur proboscidas. Nescio an scripserit A. barritus.’.

The current article aims to provide an up-to-date synopsis of available techniques to study affect dynamics using intensive longitudinal data. We do so by introducing the following eight dichotomies that help elucidate what kind of data one has, what process aspects are of interest, and what research questions are being considered: single- versus multiple-person data; univariate versus multivariate models; stationary versus nonstationary models; linear versus nonlinear models; discrete time versus continuous time models; discrete versus continuous variables; time versus frequency domain; (...) and modeling the process versus computing descriptives. In addition, we discuss what we believe to be the most urging future challenges regarding the modeling of affect dynamics. (shrink)

This book is a clear, comprehensive guide to the philosophic and religious concepts of the world's outstanding philosophers. Here are the great thoughts and ideas of the Western mind, selected and explained with magnificent precision by an eminent scholar. It is an illuminating portrait of man's intellectual and moral struggle to understand the world and the meaning of human life and destiny. Plato Aristotle Augustine Aquinas Luther Descartes Kant Rousseau Marx Nietzsche.